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This agent, which is available in 5-mg, 10-mg, and 20-mg doses, became available in 2003. These lower doses are effective because this agent has a 9-fold increase in selectivity for the specific receptor responsible for NO release in the penis. This agent can act within 20 minutes. Vardenafil has similar efficacy, side effects, and limitations as sildenafil but may be less bothered by food.
Making life style improvements (for example; quitting smoking, and exercising more),
Failure rate of 50%
The peptide Tx2-6 from the venom of the Brazilian wandering spider has recently received media attention as a potential prototype for new drugs targeting nitric oxide signaling.
Treatments (with the exception of testosterone supplementation, where effective) work on a temporary basis: they enable an erection to be attained and maintained long enough for intercourse, but do not permanently improve the underlying condition.
Success rate of 75-85%
Besides treating the underlying causes and psychological consequences, the first line treatment of erectile dysfunction consists of a trial of PDE5 inhibitor drugs (Viagra for instance or sildenafil). There are many other treatments that will be discussed on this site.
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That lack of clarity has led some to suggest that restless legs syndrome is an example of "disease mongering," in which drug companies expand the definitions of a disease to make it seem that more people need to be treated. Boosted by a widespread ad campaign, sales of Requip, one of the two FDA-approved treatments for restless legs syndrome, reached more than $500 million before the agency approved a generic form of the drug in 2008.
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Arterial Disorders (peripheral vascular disease, hypertension; reduced blood flow to the penis).
What precautions should be taken when using vardenafil (Levitra)?
"If we could re-grow and replace worn-out tissue [in other body parts], that would have tremendous implications," Sharlip said. Precautions
Vacuum constriction devices vary in cost from $300 to $500, depending on the brand and type. The battery-powered versions tend to be more expensive, but also tend to work a little more quickly. Battery-powered devices are especially helpful for men who do not have good hand strength or coordination, or who have arthritis.
Sexual counseling is the most important part of the treatment for patients with sexual problems. Many professional sexual counselors are skilled in working with patients, but the primary care physician, the urologist, and the gynecologist also serve in this capacity to some degree. These are usually the first professionals to learn about the problem, and they often have to extract the information about the sexual problem from the patient.
Sildenafil (Viagra) was the first oral phosphodiesterase type 5 (PDE5) inhibitor approved by the FDA in the United States for the treatment of erectile dysfunction (it is not approved for women). Sildenafil inhibits PDE5, which is an enzyme that destroys cGMP. By inhibiting the destruction of cGMP by PDE5, sildenafil allows cGMP to accumulate. The cGMP in turn prolongs relaxation of the smooth muscle of the corpora cavernosa. Relaxation of the corpora cavernosa smooth muscle allows blood to flow into the penis resulting in increased engorgement of the penis. In short, sildenafil increases blood flow into the penis and decreases blood flow out of the penis.
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